Compounded Semaglutide
A compounded, once-weekly subcutaneous GLP-1 receptor agonist injection. Prescribed at your clinician's discretion, started low and adjusted with you over time.
Monthly total
$299
Care $109 + Medication $190*
Dosing
Set by your clinician and adjusted over time. The price does not change with the dose.
*One monthly price across doses; your clinician sets the dose. Supplies and cold-chain shipping are included. Compounded semaglutide requires a written prescription from a licensed clinician and is not FDA-approved or evaluated for safety, effectiveness or quality. Availability of compounded semaglutide depends on federal and state rules, and your clinician will tell you when a branded product is the better choice. Evidence standards.
Start Your Assessment →What Is Semaglutide?
Semaglutide is a once-weekly GLP-1 receptor agonist. The branded product is FDA-approved for chronic weight management and has some of the largest randomized trials behind it.
We start low and step up only when each dose is comfortable, alongside protein and training guidance and a plan for what comes after.
Good to Know
- Prescribed only after a clinician reviews your history.
- Dose and course are set by your clinician, not by you.
- Results vary, and we do not promise outcomes.
Who It Is For
Eligibility
Often a Good Fit If
- ✓BMI of 30 or above, or 27 and above with a weight-related condition
- ✓Type 2 diabetes or insulin resistance alongside weight goals
- ✓Prefers to begin with a longer-established GLP-1 option
- ✓Willing to build protein and resistance training into the year
Not Prescribed If
- —Personal or family history of medullary thyroid carcinoma, or MEN 2
- —Pregnancy, breastfeeding or planning pregnancy in the near term
- —History of pancreatitis, gastroparesis or active eating disorder
- —Prior serious hypersensitivity to semaglutide or its excipients
Read Before You Decide
Key Risks, Stated Plainly
Most side effects are gastrointestinal, dose-related and worst in the days after a step-up. They usually settle. Message your clinician rather than pushing through; a slower titration fixes most of it.
Contact care the same day for
Severe or persistent abdominal pain, repeated vomiting, signs of gallbladder disease, vision changes, or a lump or swelling in the neck. Branded semaglutide carries a boxed warning for thyroid C-cell tumors based on rodent studies.
What Is Measured
Monitoring requirement: Baseline panel, dose review by response and tolerance, protein and training guidance.
Baseline Metabolic Panel
Glucose, lipids, kidney and liver markers, and HbA1c before the first dose.
Thyroid History and Function
Reviewed at baseline alongside your personal and family history.
Weight and Waist Trend
Tracked over weeks, not days. Week-to-week change is uneven.
Tolerance and Symptoms
Nausea, hydration, bowel habit and appetite shape every dose decision.
Protein and Training
Protecting lean mass is part of the plan, not an add-on.
Labs at Review
Repeated at clinician-chosen intervals to see how your body is responding.
A Clearer Path Forward
How Clinicians Review Your Response
You and Your Clinician Look at the Same Data
Symptoms you report, laboratory results and, if you connect one, wearable trends are reviewed together before any change.
A Physician-Led Review Every 90 Days
Included in your monthly price. Your clinician decides whether to continue, adjust the dose, change course or stop.
Clinical Judgment Decides
Measurements inform the decision. They do not make it, and no dashboard changes your dose on its own.
What Is Included in the Monthly Price
- ✓Named, physician-led care team
- ✓Supplies and cold-chain shipping included
- ✓Baseline laboratory panel included in your first care cycle
- ✓Physician-led review every 90 days
- ✓Dose adjusted by your clinician with no change in price
Your Care Sequence
01
Questionnaire
Share your history and goals in about ten minutes. No card required.
02
Video Visit
Meet your clinician for a full visit and leave with a written plan.
03
Delivery
If prescribed, medication ships from a licensed pharmacy, cold-chain when required, with supplies.
04
Ongoing Care
Messaging between visits, dose adjustments and a physician-led review every 90 days, included.
Common Questions About Semaglutide
How Quickly Does Semaglutide Work?+
Appetite changes are often noticeable within a few weeks, but weight change is measured in months. In the pivotal trial of the branded product the curve was still moving at 68 weeks, and the first weeks are mostly about finding a dose you tolerate.
Is Semaglutide or Tirzepatide Better for Me?+
On average, tirzepatide has produced larger weight reductions in published trials, but the right choice depends on tolerance, cost, availability and your history. Switching between them is a normal part of care.
What Happens If I Stop?+
Appetite returns and, without a maintenance plan, weight regain is common. We build the maintenance or taper plan in advance rather than treating discontinuation as an exit.
Will I Lose Muscle?+
Some lean mass is lost with any significant weight loss. Adequate protein and resistance training substantially blunt it, which is why protein and training guidance is part of every plan.
Do I Need Labs First?+
Usually yes: a recent metabolic panel, HbA1c and thyroid function at minimum. If your labs are current we will use them; otherwise we order a draw near you.
Can I Use Insurance?+
Care plans are self-pay and compounded medication is typically not covered. We provide itemized receipts for HSA/FSA and can pursue prior authorization if the branded product is appropriate for you.
Still unsure? Message the care team before you join. No account needed.
Published Research
What the Published Science Shows
~15%
Mean body-weight change at 68 weeks with semaglutide 2.4 mg in the pivotal trial of the branded product.
68 wks
Trial duration behind that figure, alongside lifestyle intervention.
~2.4%
Mean change in the placebo group over the same period, for comparison.
Figures come from the cited trials and reviews. They describe published research, not a forecast for any one person, and not a study of compounded formulations.
The Mechanism
How Semaglutide Works
GLP-1 Receptor Activation
Mimics a gut hormone released after eating, which supports satiety and glucose-dependent insulin release.
Slower Gastric Emptying
Food leaves the stomach more slowly, so meals satisfy for longer.
Appetite Signaling
Acts on hypothalamic appetite circuits, reducing the constant pull toward food.
For Readers Who Want More
Deeper Evidence
What We Can and Cannot Tell YouEvidence and regulatory status+
What the Evidence Supports
Branded semaglutide has large randomized trials in adults with overweight or obesity, and is FDA-approved for chronic weight management in that population.
What It Does Not (Yet)
Those trials studied the branded product, not compounded formulations, which the FDA has not evaluated for safety, effectiveness or quality.
Badge definitions and FDA category sourcing are on the Science page.
Illustrative Dose ScheduleFinal dose set by your clinician+
Illustrative only, based on the step pattern of the branded label. Compounded schedules vary, and your clinician sets and reviews your dose according to response and tolerance. This table is not a prescription.
| Phase | Weekly dose | Typical duration | What we watch |
|---|---|---|---|
| Initiation | 0.25 mg | 4 weeks | Nausea, hydration, protein intake |
| First step-up | 0.5 mg | 4 weeks | Appetite response, bowel habit |
| Step-up | 1.0 mg | 4 weeks | Tolerance, rate of loss |
| Higher steps | 1.7 – 2.4 mg | As indicated | Only if needed and tolerated |
| Maintenance | Lowest effective | Ongoing | Weight stability, habits, labs |
Compounded Versus Brand-NameWhat “compounded” means+
| Compounded | Brand-Name |
|---|---|
| Prepared per prescription | Manufactured at scale |
| Not FDA-approved | FDA-approved indications |
| Flexible dosing in vials | Fixed pen doses |
| Lower typical cost | Insurance may apply |
Compounded medications are prepared by a licensed pharmacy for an individual patient. We will tell you when the branded product is the better choice for your situation.
Selected Studies
Wilding et al., New England Journal of Medicine, 2021 (STEP 1)
Once-weekly semaglutide 2.4 mg plus lifestyle intervention produced sustained weight loss in adults with overweight or obesity.
See Whether Semaglutide Is Right for You
Ten minutes, no card, reviewed by a clinician.